Uvuma-omhlope : Synaptolepis kirkii

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0><tr> <td valign="top" colspan=2 height=90 BGCOLOR="#006699" TEXT="#080000" background="04afd5a3.jpg"> <bR> <div> <B>The Botanical Source</B></div> <div> </div> </td> </tr><tr> <td valign="top" width=210 BGCOLOR="#FFCC66" TEXT="#080000" background="04bd2063.jpg"> <div> <A HREF="index.htm" TARGET="_top" TITLE="The Botanical Source"><U><B><IMG SRC="107b8d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></U></A></div> <div> <A HREF="http://www.thebotanicalsource.com/shop/index.php?cPath=21" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/i"><U><IMG SRC="11958d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id22.htm" TARGET="_top" TITLE="A wide range of indigenous seeds from Af"><U><IMG SRC="11948d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="http://www.thebotanicalsource.com/shop/index.php?cPath=28&osCsid=5d55fa2bee3df7b388a151625a1e9916" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/i"><U><IMG SRC="11938d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id28.htm" TARGET="_top" TITLE="Articles about African indigenous healin"><U><IMG SRC="10828d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id20.htm" TARGET="_top" TITLE="Contact Us"><U><IMG SRC="11928d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id23.htm" TARGET="_top" TITLE="Photo Gallery"><U><IMG SRC="11918d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div>   <script type="text/javascript" src="http://edge.quantserve.com/quant.js"></script> <script type="text/javascript">_qacct="p-41ZhKYiACxjoQ";quantserve();</script> <noscript> <a href="http://www.quantcast.com/p-41ZhKYiACxjoQ" target="_blank"><img src="http://pixel.quantserve.com/pixel/p-41ZhKYiACxjoQ.gif" style="display: none;" border="0" height="1" width="1" alt="Quantcast"/></a> </noscript>   </div> <div>  <script type="text/javascript"> var gaJsHost = (("https:" == document.location.protocol) ? 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They have brown fibres embedded in them, and appear like pieces of plaster of Paris.</B></div> <bR> <div> <B><IMG SRC="87ca90c0.jpg" border=0 width="425" height="268" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <B>Botanical description</B><B> :</B></div> <bR> <div> <B>The plant is a multi-branched, scandent shrub with dark brown, almost black stems and bluish-green spear-shaped leaves between 1 and 2cm long. The plant has a bluish-green colour whilst the fibrous roots are a striking porcelain white. Below the ground is a large tuberous root. The leaves have virtually no stalks, are about 25mm long and are arranged in opposite pairs. Tubular whitish flowers with orange pollen of about 15mm long are borne in small groups. The fruits are orange and superficially berry-like, but each fruit is actually enclosed within the persistent basal part of the flower, which forms a slightly fleshy covering. The tasty round fruit is yellow-orange when ripe.</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <B><IMG SRC="e351ac50.jpg" border=0 width="282" height="197" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <div> <B>[ The anatomy of the leaf of Synaptolepis kirkii. ]</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <B>Active ingredients</B><B> : </B></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">An unusual diterpenoid ester known as Synaptolepis factor K, has been reported from a Synaptolepis species (see Zayed 1977).</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <B>Pharmacological effects</B><B> : </B></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">See</B><B> `Kirkinine, a New Daphnane Orthoester with Potent </B><FONT SIZE="4" COLOR="#800080" FACE="Arial" ><B>Neurotrophic</B></FONT><B> Activity from Synaptolepis kirkii' </B><B>by authors He W; Cik M; Lesage A; Linden IVD; Kimpe ND; Appendino G; Bracke J; Mathenge SG; Mudida FP; Leysen JE; Puyvelde LV in the </B><B>Journal of Natural Products</B><B>, 63(9): pp. 1185-1192, 2000 </B><FONT SIZE="4" COLOR="#111111" FACE="Arial" ><B>ISSN</B><B>:</B></FONT><FONT SIZE="4" COLOR="#808080" FACE="Arial" ><B> </B></FONT><B>0163-3864.</B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Abstract : The bioassay-guided fraction of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as </B><B>a powerful neurotrophic constituent</B><B>. </B></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Bioorg Med Chem. 2002 Oct;10(10):3245-55. </B><B>Neurotrophic</B><B> and antileukemic daphnane diterpenoids from Synaptolepis kirkii.</B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Abstract : Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. </B><B>Pronounced neurotrophic</B><B> and substantial antileukaemia activities of these compounds were found in in-vitro assays.</B></div> <bR> <div> <B><U>What are neurotrophins</U></B><FONT SIZE="4" COLOR="#000000" FACE="Arial" ><B>? :</B></FONT></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Neurotrophins are a family of molecules that encourage survival of nervous tissue.</B></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">A molecule, usually a protein, that will facilitate the growth or repair of nerve cells.</B></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">A protein, such as nerve growth factor, that promotes nerve cell growth and survival.</B></div> <bR> <div> <B>For further information about neurotrophins & neurogenesis see :</B></div> <bR> <div> <A HREF="http://en.wikipedia.org/wiki/Neurotrophic_factor" TARGET="_blank" TITLE="http://en.wikipedia.org/wiki/Neurotrophi"><U>http://en.wikipedia.org/wiki/Neurotrophic_factor</U></A></div> <bR> <div> <A HREF="http://www.princeton.edu/pr/news/99/q4/1014-brain.htm" TARGET="_blank" TITLE="http://www.princeton.edu/pr/news/99/q4/1"><U>http://www.princeton.edu/pr/news/99/q4/1014-brain.htm</U></A></div> <div> Scientists Discover Addition of New Brain Cells in Highest Brain Area</div> <bR> <div> <A HREF="http://www.psychiatrist.com/pcc/brainstorm/br5904.htm" TARGET="_blank" TITLE="http://www.psychiatrist.com/pcc/brainsto"><U>http://www.psychiatrist.com/pcc/brainstorm/br5904.htm</U></A></div> <div> Neurotrophic factors.</div> <bR> <div> <A HREF="http://www.seedmagazine.com/news/2006/02/the_reinvention_of_the_self.php?page=all&p=y " TARGET="_blank" TITLE="http://www.seedmagazine.com/news/2006/02"><U>http://www.seedmagazine.com/news/2006/02/the_reinvention_of_the_self.php?page=all&p=y</U></A></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <B>Propagation from seed</B><B> :</B><FONT SIZE="3" COLOR="#000000" FACE="Arial" ><B> </B></FONT></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Soak the seeds overnight to assist with the removal of the pulpy outer covering. Then sow the seeds into a well-drained seedling medium. The plants should be left to grow out of the container before they are transplanted straight into the ground.</B></div> <bR> <div> <B>Vegetative propagation</B><B> : </B></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Cuttings can be used to propagate the plants asexually.</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=22&products_id=52" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><B>Click here to buy uvuma-omhlope</B></U></A><B>.</B></div> <div> <A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=28&products_id=71" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><B>Click here to buy uvuma-omhlope tincture</B></U></A><B>.</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <B>  Subscribe to The Botanical Source free newsletter:<br><br> <form action="http://freeautobot.com/cgi-bin/autores/autores.cgi" target="_blank"> <input type=hidden name="do" value="add_lead_external"> <input type=hidden name="Username" value="botanical"> <input type=hidden name="Stop_Status" value="Active"> <input type=hidden name="Cycle_Number" value="0"> <input type=hidden name="Success_URL" value="http://www.thebotanicalsource.com/id310.htm"> <input type=hidden name="Failure_URL" value="http://www.thebotanicalsource.com/id309.htm"> <input type=hidden name="Notes" value="Added from opt-in form"> Email : <input type=text name="Email" value=""><br> <input type=submit value="Submit"> </form>   </B></div> <div> <B>[ Opens a new window. ]</B></div> <bR> <div> <B>Privacy Policy</B><FONT SIZE="1" COLOR="#000000" FACE="Arial" ><B> :</B></FONT></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700a000000000.png" HEIGHT="11" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">We do not publish or share your email address with anyone.</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <A HREF="#top" TITLE="Uvumaomhlope : Synaptolepis kirkii"><U><B>Top</B></U></A><B>.</B></div> <bR> <div>  <script type="text/javascript"> </script> <script type="text/javascript" src="http://pagead2.googlesyndication.com/pagead/show_ads.js"> </script>  </div> <div> <A HREF="http://www.thebotanicalsource.com/shop" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop"><U><B>Click here to return to Herbal Products</B></U></A><B>.</B></div> <bR> <div> <A HREF="id21.htm" TARGET="_top" TITLE="The Botanical Source"><U><B>Return to Articles.</B></U></A></div> <bR> </td> </tr></table></body>