Picralima nitida

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0><tr> <td valign="top" colspan=2 height=90 BGCOLOR="#006699" TEXT="#080000" background="04afd5a3.jpg"> <bR> <div> <B>The Botanical Source</B></div> <div> </div> </td> </tr><tr> <td valign="top" width=210 BGCOLOR="#FFCC66" TEXT="#080000" background="04bd2063.jpg"> <div> <A HREF="index.htm" TARGET="_top" TITLE="The Botanical Source"><U><B><IMG SRC="107b8d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></U></A></div> <div> <A HREF="http://www.thebotanicalsource.com/shop" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop"><U><IMG SRC="11958d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id22.htm" TARGET="_top" TITLE="Seed Catalogue :"><U><IMG SRC="11948d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="http://www.thebotanicalsource.com/shop/index.php?cPath=28&osCsid=5d55fa2bee3df7b388a151625a1e9916" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/i"><U><IMG SRC="11938d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id28.htm" TARGET="_top" TITLE="Articles about African indigenous healin"><U><IMG SRC="10828d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id20.htm" TARGET="_top" TITLE="Contact Us"><U><IMG SRC="11928d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div> <A HREF="id23.htm" TARGET="_top" TITLE="Photo Gallery"><U><IMG SRC="11918d140.png" border=0 width="141" height="20" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></U></A></div> <div>   <script type="text/javascript" src="http://edge.quantserve.com/quant.js"></script> <script type="text/javascript">_qacct="p-41ZhKYiACxjoQ";quantserve();</script> <noscript> <a href="http://www.quantcast.com/p-41ZhKYiACxjoQ" target="_blank"><img src="http://pixel.quantserve.com/pixel/p-41ZhKYiACxjoQ.gif" style="display: none;" border="0" height="1" width="1" alt="Quantcast"/></a> </noscript>   </div> <div>  <script type="text/javascript"> var gaJsHost = (("https:" == document.location.protocol) ? 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It causes marked and lasting hypotension in dogs, without affecting respiration. In higher doses it causes a strong inhibitory effect on intestinal peristaltic movements. At such doses it also has hypertensive activity with a weaker, but longer lasting effect than yohimbine.</div> <div> <IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Akuammigine shows clear sympatholytic activity and antagonizes the effect of adrenaline on the heart, vessels and regulatory centre of the circulation system. Akuammidine has hypotensive, skeletal muscle relaxant and local analgesic activities. Its local analgesic activity is about 3 times as potent as cocaine. It acts selectively as a sympatholytic, unaccompanied by parasympatholytic effects. It inhibits the irritability of the sympathetic nervous system and opposes akuammine. Pseudo-akuammigine acts as an indirect reversible and competitive parasympathomimetic. In low doses it excites and in high doses it inhibits the central nervous system, respiration, contraction of the skeletal muscles and contraction of the smooth muscles. It increases hexobarbital-induced sleeping time and has local analgesic, anti-inflammatory, cholinesterase-inhibiting and hypotensive activities. </div> <div> <IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">A new indole alkaloid, picranitine, has been isolated from the seeds of Picralima nitida, along with five known indole alkaloids picratidine, akuammine, pseudoakuammine, akuammicine and akuammidine.</div> <div> <IMG BORDER="0" SRC="Symb075c00b7011800000000.png" HEIGHT="19" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The seeds are particularly rich in alkaloids (3.5–4.8%); akuammine is the principal alkaloid of the mature seeds, while minor alkaloids are pseudo-akuammicine, picranitine, picratidine (N-methylpicraline), eburnamine (desacetylpicraline) and desacetylakuammiline (rhazimol).</div> <div> <B>____________________________________________________________</B></div> <bR> <div> <A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=25&products_id=69" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><B>Click here to buy </B></U></A><A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=25&products_id=69" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><I><B>Picralima nitida</B></I></U></A><A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=25&products_id=69" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><B> seeds</B></U></A><B>.</B></div> <bR> <div> <A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=28&products_id=115" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><B>Click here to buy </B></U></A><A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=28&products_id=115" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><I><B>Picralima nitida</B></I></U></A><A HREF="http://www.thebotanicalsource.com/shop/product_info.php?cPath=28&products_id=115" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop/p"><U><B> seeds tincture</B></U></A><B>.</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <B>  Subscribe to The Botanical Source free newsletter:<br><br> <form action="http://freeautobot.com/cgi-bin/autores/autores.cgi" target="_blank"> <input type=hidden name="do" value="add_lead_external"> <input type=hidden name="Username" value="botanical"> <input type=hidden name="Stop_Status" value="Active"> <input type=hidden name="Cycle_Number" value="0"> <input type=hidden name="Success_URL" value="http://www.thebotanicalsource.com/id310.htm"> <input type=hidden name="Failure_URL" value="http://www.thebotanicalsource.com/id309.htm"> <input type=hidden name="Notes" value="Added from opt-in form"> Email : <input type=text name="Email" value=""><br> <input type=submit value="Submit"> </form>   </B></div> <div> <B>[ Opens a new window. ]</B></div> <bR> <div> <B><U>Privacy Policy</U></B><FONT SIZE="1" COLOR="#000000" FACE="Arial" ><B> :</B></FONT></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700a000000000.png" HEIGHT="11" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">We do not publish or share your email address with anyone.</B></div> <div> <B>____________________________________________________________</B></div> <bR> <div> <A HREF="http://www.thebotanicalsource.com/shop" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop"><U><B>Return to Herbal Products</B></U></A><A HREF="http://www.thebotanicalsource.com/shop" TARGET="_top" TITLE="http://www.thebotanicalsource.com/shop"><U><B>.</B></U></A></div> <bR> <div> <A HREF="id28.htm" TARGET="_top" TITLE="Articles about African indigenous healin"><U><B>Return to Articles.</B></U></A></div> <bR> </td> </tr></table></body>