(synonyms = Desmanthus nutans, Desmanthus trichostachys. There are two other Desmanthus species currently used as ayahuasca analogues.)

Roots are an ingredient in a decoction taken to ease pain or rubbed into incisions cut over the painful area.

The root is used in East Africa as an aphrodisiac.

Bark is used as a ritual cleanser or for ritual cleansing.

The Pedi & Lobedu of South Africa use the pods to remove evil spirits.

The presence of alkaloids and saponins have been indicated in the roots and leaves.