Leaf decoctions are used as analgesics in central Africa.
Narcotic effects are reported from Mauritius.
Roots are used as an aphrodisiac in Zimbabwe.
In Madagascar the fruit on the west coast are the chief source of alcohol for the people.
Certain South African tribes use the plant in death ceremonies.

The alkaloid harmin has been found in bark and leaves of Strychnos usambarensis.
Beta-carbolines are also reputedly found in Strychnos melinoniana.
The root of Strychnos madagascariensis is used in sangoma (indigenous diviner) initiations.

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