The uses of Voacanga thouarsii are similar to those of Voacanga africana.
The root bark of Voacanga species is generally ingested to combat fatigue and increase endurance of drummers and hunters and, in higher doses, also for magic and religious purposes.

Seeds of Voacanga thouarsii and Voacanga africana appear to be the best sources of tabersonin, and V. thouarsii seeds are reported to give a higher yield in tabersonin than V. africana seeds.
The discovery of the transformation of tabersonin into vincamine in two steps opened a new way for the commercial exploitation of Voacanga seeds (Zsadon, 1982).
Vincamine is used for the treatment of cerebral vascular disorders.
Enhances memory and mental alertness.

The seeds of V. africana are used for magical purposes in West Africa.
V. africana is known to contain ibogaine like alkaloids.

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